Endocrine Abstracts

Development of a functional human lung requires regulation of cell growth, proliferation and differentiation in specific germ layer compartments. Important endocrine regulators of respiratory development include glucocorticoid (GC) steroids and the potent synthetic GC betamethasone is commonly used antenatally to treat the deficits of very preterm human birth. Previous studies with conditional mouse knockouts of the glucocorticoid receptor (GR) gene have established the mesenc...